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Mineral BalanceUpdated 2025-12-24Medically Reviewed

Ionized Calcium

Everything you need to know about Ionized Calcium levels, including what normal ranges look like and what abnormal results might indicate.

Standard Reference Range

Unit: mmol/L
Male Reference Range
1.12–1.32 mmol/L
Female Reference Range
1.12–1.32 mmol/L
i

Reference ranges may vary slightly between laboratories. Always consult your doctor for interpretation.

What is Ionized Calcium?

Ionized calcium measures the biologically active, unbound fraction of calcium in blood, unaffected by albumin levels.

Key Takeaway

When albumin is low or pH is abnormal, ionized calcium gives a truer picture than total calcium.

Why is this test performed?

  • Evaluate symptoms like tingling, muscle cramps, or arrhythmias
  • Assess critical illness, kidney disease, or parathyroid disorders
  • Monitor transfusions or large volume IV fluids that alter pH

Interpreting Your Results

  • High: Hyperparathyroidism, malignancy, vitamin D excess, acidosis
  • Low: Hypoparathyroidism, vitamin D deficiency, pancreatitis, alkalosis, citrate from transfusions

Related Tests

  • Calcium: Total level; may mislead when albumin is low
  • Albumin: Binds calcium; adjust total calcium if ionized not available
  • Magnesium/Phosphorus: Move with calcium in many disorders

Decode your Ionized Calcium Results

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Ionized Calcium Levels: Normal Range, High & Low Meaning | WellAlly