InflammationUpdated 2025-12-24Medically Reviewed
High-Sensitivity C-Reactive Protein (hs-CRP)
Everything you need to know about High-Sensitivity C-Reactive Protein (hs-CRP) levels, including what normal ranges look like and what abnormal results might indicate.
Standard Reference Range
Unit: mg/LMale Reference Range
<1.0 (optimal <0.5) mg/L
Female Reference Range
<1.0 (optimal <0.5) mg/L
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Reference ranges may vary slightly between laboratories. Always consult your doctor for interpretation.
What is hs-CRP?
hs-CRP is a sensitive marker of systemic inflammation. Persistent elevation correlates with higher cardiovascular and metabolic risk.
Risk bands
＜1.0 low risk · 1.0–3.0 moderate · ＞3.0 high (repeat to confirm; rule out infection).
Why it’s ordered
- Cardiometabolic risk stratification
- Tracking response to lifestyle changes (sleep, body composition, nutrition)
- Checking for hidden inflammation when other labs look normal
Interpreting patterns
- Mild elevation with high triglycerides/low HDL: think insulin resistance, visceral fat
- Elevation with dental issues/poor sleep: address oral health and sleep debt
- ＞3.0 without infection: seek medical evaluation to exclude infection, autoimmune, or other causes
How to lower hs-CRP
- Improve sleep duration/regularity; manage stress
- Reduce refined carbs and ultra-processed foods; add omega-3s
- Increase activity (Zone2 + strength); reduce visceral fat
- Address gum disease or chronic infections with a clinician
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