InflammationUpdated 2025-12-24Medically Reviewed
Homocysteine
Everything you need to know about Homocysteine levels, including what normal ranges look like and what abnormal results might indicate.
Standard Reference Range
Unit: µmol/LMale Reference Range
<15 (optimal 6-8) µmol/L
Female Reference Range
<15 (optimal 6-8) µmol/L
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Reference ranges may vary slightly between laboratories. Always consult your doctor for interpretation.
What is homocysteine?
Homocysteine is an amino acid that reflects methylation status and endothelial health. Elevated levels may indicate B-vitamin insufficiency or higher cardiovascular risk.
Optimal window
Aim for 6–8 µmol/L; ＞10 warrants lifestyle/nutrition attention; ＞15 needs clinical review.
Why test it?
- Cardiovascular and stroke risk refinement
- Clues to B12/folate/B6 status or MTHFR variants
- Can rise with hypothyroidism, kidney impairment, high coffee intake, or smoking
How to lower levels
- Ensure adequate folate (leafy greens), B12 (animal foods or supplements), B6
- Optimize thyroid function if TSH high
- Reduce smoking and excessive coffee/alcohol
Pair with
- Vitamin B12 and folate for deficiency confirmation
- Thyroid panel when TSH is elevated
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