AST (Aspartate Aminotransferase)
Everything you need to know about AST (Aspartate Aminotransferase) levels, including what normal ranges look like and what abnormal results might indicate.
Standard Reference Range
Unit: U/LReference ranges may vary slightly between laboratories. Always consult your doctor for interpretation.
What is AST?
Aspartate Aminotransferase (AST) is an enzyme found in various tissues including the liver, heart, muscles, kidneys, and brain. When these tissues are damaged, AST is released into the bloodstream.
Key Takeaway
AST is less specific than ALT for liver damage as it can come from multiple organs. The AST/ALT ratio helps determine the source of elevation.
Why is this test performed?
AST is commonly ordered alongside ALT to:
- Assess liver function and detect liver damage
- Differentiate between liver and heart/muscle damage
- Monitor chronic liver disease progression
- Evaluate medication side effects
Interpreting Your Results
High Levels (Elevated AST)
Mild to Moderate Elevation:
- Fatty liver disease
- Chronic hepatitis
- Medication-induced liver injury
- Muscle injury or strenuous exercise
Severe Elevation:
- Acute viral hepatitis
- Drug/toxin-induced liver damage
- Heart attack (myocardial infarction)
- Severe muscle injury
AST/ALT Ratio
- Ratio ＜ 1: Suggests chronic hepatitis or fatty liver
- Ratio ＞ 2: May indicate alcoholic liver disease or cirrhosis
- Ratio ≈ 1: Common in acute hepatitis
Related Tests
Check these tests together with AST for a complete picture:
- ALT: Primary liver enzyme marker
- GGT: Helps confirm liver origin
- ALP: Indicates bile duct issues
- Bilirubin: Measures liver's processing function
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