Statins (HMG-CoA Reductase Inhibitors)
Generic name: Atorvastatin / Rosuvastatin / Simvastatin / Pravastatin | Common brands: Lipitor, Crestor, Zocor, Pravachol
Why statins?
They reduce hepatic cholesterol synthesis, upregulate LDL receptors, and robustly lower LDL/ApoB, cutting ASCVD events across risk groups.
Choosing an agent
- High intensity: atorvastatin 40–80 mg, rosuvastatin 20–40 mg
- Moderate: atorvastatin 10–20 mg, rosuvastatin 5–10 mg, simvastatin 20–40 mg
- Consider drug interactions (simvastatin/lovastatin CYP3A4); pravastatin/rosuvastatin have fewer interactions.
Monitoring
- Baseline and follow-up [ALT]/[AST]; CK if muscle symptoms.
- Recheck lipids/ApoB 4–12 weeks after start or dose change, then 3–12 months.
Safety notes
- Muscle symptoms: stop and evaluate CK/renal function if severe; consider rechallenge with lower dose/alternate statin.
- Pregnancy: avoid; stop when planning pregnancy unless specialist advises otherwise.
When to add-on
- If ApoB goal unmet, add ezetimibe or PCSK9i per clinician.
Related drug cards
Medical Disclaimer: Education only; not medical advice.
🧪 Key Lab Tests to Monitor
Doctors often track these specific indicators to ensure Statins (HMG-CoA Reductase Inhibitors) is working safely and effectively:
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⚠️ Medical Disclaimer
The information provided here is for educational purposes only and is not intended as medical advice. Always consult with your healthcare provider regarding your medications and lab results. Do not stop taking any medication without talking to your doctor.