Glipizide

What is Glipizide?

Glipizide is a sulfonylurea that stimulates the pancreas to release more insulin, lowering blood sugar in type 2 diabetes.

How it works

It closes ATP-sensitive potassium channels on pancreatic beta cells, triggering insulin release when glucose is present. This reduces fasting and meal-time glucose levels.

Common uses

• Add-on to metformin when extra glucose lowering is needed
• Alternative for patients seeking lower-cost oral options
• Short-term therapy when other agents are being adjusted

Monitoring & Safety

• Labs: Regular glucose checks and hba1c every 3 months. Monitor egfr and creatinine for dose considerations in kidney disease.
• Risk of low blood sugar increases if meals are skipped or doses are high.

Dosing (简要)

• Immediate-release usually before breakfast; extended-release with breakfast.
• Start low (2.5-5 mg) and titrate every 1-2 weeks based on readings and hypoglycemia risk.

Drug interactions

• Alcohol, other diabetes meds, and certain antibiotics can potentiate hypoglycemia.
• Corticosteroids may raise glucose, requiring temporary dose changes.

Patient tips

• Eat consistent meals and carry quick sugar sources.
• If a dose is missed near mealtime, skip rather than double later.
• Track readings in a log or app to share with your care team.

When to contact your doctor

• Repeated low sugars, especially overnight.
• Blurry vision, shaking, or confusion that does not improve with carbs.
• Persistent high sugars despite dose increases.

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Medical Disclaimer: 本内容仅供教育用途，不能替代专业医疗建议。