Protein StatusUpdated 2025-12-24Medically Reviewed
Total Protein
Everything you need to know about Total Protein levels, including what normal ranges look like and what abnormal results might indicate.
Standard Reference Range
Unit: g/dLMale Reference Range
6.0–8.3 g/dL
Female Reference Range
6.0–8.3 g/dL
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Reference ranges may vary slightly between laboratories. Always consult your doctor for interpretation.
What is Total Protein?
Total Protein measures the combined amount of albumin and globulins in your blood. It reflects nutritional status, liver function, and immune protein production.
Key Takeaway
A high or low total protein should be split into albumin and globulin components to find the real cause.
Why is this test performed?
- Screen nutrition and hydration status
- Evaluate liver or kidney disease
- Investigate swelling, fatigue, or weight loss
- Monitor chronic illnesses (e.g., hepatitis, autoimmune disease)
Interpreting Your Results
High Total Protein
- Chronic inflammation or infection
- Monoclonal gammopathy (e.g., multiple myeloma)
- Dehydration (concentrates proteins)
Low Total Protein
- Malnutrition or malabsorption
- Liver disease (reduced protein synthesis)
- Kidney loss (nephrotic syndrome)
- Dilution from overhydration
Related Tests
- Albumin: Major contributor; low albumin suggests liver/kidney or nutrition issues
- Bilirubin: Helps judge liver synthetic vs excretory function
- Calcium/Magnesium: Bind to albumin; levels can shift with protein changes
Decode your Total Serum Protein Results
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