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Lipid PanelUpdated 2025-12-24Medically Reviewed

HDL Cholesterol

Everything you need to know about HDL Cholesterol levels, including what normal ranges look like and what abnormal results might indicate.

Standard Reference Range

Unit: mg/dL
Male Reference Range
>40 mg/dL
Female Reference Range
>50 mg/dL
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Reference ranges may vary slightly between laboratories. Always consult your doctor for interpretation.

What is HDL?

HDL (High-Density Lipoprotein) is the "good" cholesterol that removes excess cholesterol from arteries and transports it to the liver for disposal.

Key Takeaway

Higher HDL levels are protective against heart disease. HDL acts as a "cholesterol vacuum cleaner" for your arteries.

Why is this test performed?

HDL testing helps:

  • Assess cardiovascular disease risk
  • Evaluate overall lipid profile
  • Guide treatment decisions
  • Monitor lifestyle interventions
  • Identify metabolic syndrome

Interpreting Your Results

HDL Categories

Low (Increased Risk):

  • Men: <40 mg/dL
  • Women: <50 mg/dL
  • Major risk factor for heart disease

Acceptable:

  • 40-59 mg/dL: Moderate protection

High (Protective):

  • ≥60 mg/dL: Protective against heart disease
  • Considered a "negative risk factor"

Very High HDL

  • >100 mg/dL: Generally beneficial
  • Rare cases: May indicate CETP deficiency or alcohol excess
  • Usually not concerning

Causes of Low HDL

Lifestyle Factors:

  • Smoking (most significant)
  • Sedentary lifestyle
  • Obesity (especially abdominal)
  • High carbohydrate diet

Medical Conditions:

  • Metabolic syndrome
  • Type 2 diabetes
  • Hypertriglyceridemia

Medications:

  • Beta-blockers
  • Anabolic steroids
  • Progestins

Genetic:

  • Familial hypoalphalipoproteinemia

Raising HDL

Most Effective Strategies:

  • Exercise: Most powerful intervention (increase 5-10%)
  • Quit smoking: Can raise HDL by 10%
  • Lose weight: Each 6 lbs lost raises HDL ~1 mg/dL
  • Moderate alcohol: May increase HDL (but weigh risks)

Dietary Changes:

  • Replace saturated fats with unsaturated fats
  • Add omega-3 fatty acids (fish)
  • Reduce refined carbohydrates
  • Include nuts and olive oil

Medications (Limited Options):

  • Niacin (modest effect, side effects)
  • Fibrates (modest effect)
  • No medication specifically approved for low HDL

HDL Functionality

Recent research shows HDL quality matters as much as quantity:

  • Functional HDL: Effectively removes cholesterol
  • Dysfunctional HDL: May not be protective

Total/HDL Ratio

This ratio predicts risk:

  • <3.5: Optimal
  • 3.5-5: Average risk
  • >5: Increased risk

Important Notes

  • HDL benefits plateau above certain levels
  • Medications that raise HDL haven't always reduced heart disease
  • Focus on improving all cardiovascular risk factors, not just HDL

Related Tests

  • ApoA1: Main protein in HDL
  • HDL-P: HDL particle number
  • Triglycerides: Inversely related to HDL

Decode your HDL Cholesterol Results

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HDL Cholesterol Levels: Normal Range, High & Low Meaning | WellAlly